Fermentation Process Development Engineer - PhD Level Job at Eurofins, San Carlos, CA

  • Eurofins
  • San Carlos, CA

Job Description

Eurofins PSS seeks a PhD-level scientist to lead development and scale-up of E. coli fermentation processes for a proprietary DNA manufacturing platform. The role spans bench to pilot scale, encompassing process design, optimization, documentation, and technology transfer to external manufacturing partners.

Responsibilities

  • Design, execute, and optimize E. coli fermentation processes from shake flask through pilot-scale bioreactors
  • Drive yield and consistency improvements through systematic optimization of strain, media, feed strategy, and process parameters
  • Define process design space and identify critical process parameters using design of experiments methodology
  • Establish scale-independent criteria to ensure bench-scale performance is reproducible at larger scales
  • Author technical documentation and generate packages supporting GLP studies and technology transfer to external partners

Requirements

  • PhD in chemical engineering, biochemical engineering, biotechnology, microbiology, or related field
  • 1+ years hands-on bacterial fermentation process development in instrumented bioreactors
  • Experience independently designing and executing fermentation experiments at ≥2 L working volume
  • Demonstrated proficiency with design of experiments and statistical analysis methods
  • Strong technical writing skills evidenced by development reports, protocols, or publications
  • Hands-on experience with modern bioreactor control platforms (Sartorius, Eppendorf/DASGIP, or Ambr)
  • Experience with high-cell-density fed-batch E. coli fermentation and scaling constraints

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